cell biology papers | Gist.Science

New three-dimensional preclinical models to understand and treat liver cancers activated for the β-catenin pathway

This study establishes a robust, dynamic suspension culture method using rotating bioreactors to generate uniform, viable 3D organoids and tumouroids from mouse models of beta-catenin-activated liver cancers, which successfully recapitulate native tissue features and demonstrate responsiveness to the beta-catenin antagonist WNTinib for future drug screening and personalized therapy development.

Bou Malham, V., Leandre, F., Hamimi, A. + 5 more2026-04-03📄 cell biology

Targeting TPO/MPL Signaling to Mitigate JAK2V617F-driven Cardiac Microvascular Disease

This study demonstrates that JAK2V617F-mutant hematopoiesis drives cardiac microvascular disease and endocardial injury through upregulated TPO/MPL signaling in endocardial endothelial cells, a pathological process that can be effectively mitigated by neutralizing MPL.

Yang, X., Masarik, K., Sun, X. + 4 more2026-04-03📄 cell biology

Cholesterol-dependent lysosomal docking of mTORC1 mediated by TM6SF1

This study identifies TM6SF1 as a cholesterol-bound lysosomal membrane protein that structurally stabilizes the Ragulator complex to facilitate mTORC1 docking, thereby linking lysosomal cholesterol levels directly to growth control and TFEB regulation.

Hong, S., Jia, L., Wang, R. + 3 more2026-04-03📄 cell biology

The role of N-glycans and their processing in ER-to-lysosome-associated degradation of disease-causing mutant Neuroserpin

This study demonstrates that the disease-causing Portland variant of Neuroserpin is cleared via the ER-to-lysosome-associated degradation (ERLAD) pathway, where persistent glucosylation of its N-glycan at position 321 recruits the chaperone Calnexin to initiate LC3-dependent autophagic delivery to lysosomes through the FAM134B receptor and Syntaxin17.

Fregno, I., Hoefner, C., Molinari, M.2026-04-03📄 cell biology

A stage-resolved map of dynamic septin interactions required for infection by the rice blast fungus

This study establishes a quantitative, stage-resolved interactome of septins in the rice blast fungus *Magnaporthe oryzae*, revealing their dynamic role in coordinating membrane remodeling, metabolism, and virulence factors essential for appressorium-mediated plant infection.

Eisermann, I., Sahu, N., Garduno-Rosales, M. + 4 more2026-04-03📄 cell biology

Unconventional Interplay Between GPCRs and RTKs Signaling Pathways Through SH2 Domain-Containing Proteins

This study reveals that activation of Gq/11 and G12/13-coupled GPCRs triggers the dissociation of SH2 domain-containing proteins from the plasma membrane and their subsequent nuclear accumulation, thereby suppressing RTK signaling activity through a previously uncharacterized crosstalk mechanism.

Scarpelli Pereira, P. H., Mancini, A., Sidiki Traore, B. + 5 more2026-04-03📄 cell biology

DNA damage drives a unique, Alzheimer's disease-relevant senescent state in neurons

This study demonstrates that DNA damage drives a unique, p21-associated senescent-like state in neurons characterized by a senescence-associated secretory phenotype (SASP) and NF-κB1 activation, which transcriptionally mirrors Alzheimer's disease pathology and differs significantly from the p16-associated, SASP-lacking senescence observed in fibroblasts.

Hughes, J.-W. B., Sandholm, A., Croll, D. + 18 more2026-04-03📄 cell biology

Spatiotemporal organization of dynein in bulk cytoplasm promotes aster growth and positioning in large embryos

This study reveals that in large medaka embryos, the spatiotemporal reorganization of cytoplasmic dynein from a metaphase aster periphery halo to anaphase asters and organelles coordinately drives both aster growth and centrosome pulling to ensure proper cell division geometry.

Kiyomitsu, A., Bai, L., Mitchison, T. + 1 more2026-04-03📄 cell biology

The Hippo Signaling Pathway Regulates Corneal Endothelial Regeneration

This study identifies the Hippo signaling pathway as a conserved regulator of corneal endothelial regeneration, demonstrating that inhibiting this pathway to activate YAP promotes wound healing in both rodent and primate models, thereby offering a novel therapeutic target for treating corneal endothelial decompensation.

Zhuang, J., Guo, Y., Zhang, H. + 14 more2026-04-02📄 cell biology

Stem cell control and cancer initiation by an autocrine, injury-activated Igf complex

This study reveals that the Igf2-Igf binding protein complex, which is sequestered in neuroendocrine stem cells until injury releases it to drive proliferation via Rb repression, serves as a critical mechanism linking tissue repair to the initiation of small cell lung cancer.

Zhang, Y., Ouadah, Y., Liu, Y. + 3 more2026-04-02📄 cell biology

Metabolostasis failure thresholds are linked with network topology, metabolite solubility, and translational control

This study reveals that cellular metabolostasis failure thresholds and toxicity mechanisms in *Saccharomyces cerevisiae* are determined by the interplay of metabolite network topology, chemical solubility, and a two-tiered translational control system that coordinates general resource conservation with metabolite-specific defense strategies to prevent amyloid-like aggregation.

A. Levkovich, S., M Lim, C., A. Marzini, E. + 11 more2026-04-02📄 cell biology

AI-Driven Reconstruction of the Research Paradigm for Phase Separation in Membraneless Organelle

This study proposes a novel three-stage AI-driven research paradigm that integrates adversarial training and non-equilibrium thermodynamics to evolve protein phase separation prediction from simple binary classification into a robust framework capable of physical mechanism analysis and the discovery of new membraneless organelles.

ding, y., lu, t., Li, y.2026-04-02📄 cell biology

Ovarian extracellular matrix mechanics regulate oocyte-follicle interactions during female reproductive aging

This study demonstrates that age-related stiffening of the ovarian stromal extracellular matrix impairs oocyte quality and granulosa cell-oocyte interactions by dysregulating TGF-β signaling, a dysfunction that can be rescued by activating this pathway.

Shen, X., Wang, H., Cao, G. + 8 more2026-04-02📄 cell biology

SHOT-CCR: Biologically guided adversarial training for test-time adaptation in cellular morphology

The paper introduces SHOT-CCR, a biologically guided test-time adaptation framework that leverages cell-invariant gradient reversal to decouple morphological signals from batch effects, achieving state-of-the-art accuracy in classifying genetic perturbations across diverse Cell Painting datasets.

Dee, W., Wenteler, A., Seal, S. + 2 more2026-04-02📄 cell biology

ER discontinuities are common in C. elegans neurons, revealing a genetically tractable model for ER network maintenance

This study reveals that micron-scale endoplasmic reticulum (ER) discontinuities are a common, dynamic, and rapidly resolved feature of healthy *C. elegans* neurons that increase with age, stress, and specific genetic impairments, establishing a tractable model for investigating the molecular mechanisms of ER network maintenance in vivo.

Mabry, K. N., Donahue, E. K. F., Orgel, A. D. + 3 more2026-04-02📄 cell biology

Generative machine learning unlocks the first proteome-wide image of human cells

This paper introduces ProtiCelli, a deep generative model trained on the Human Protein Atlas that synthesizes proteome-wide, spatially resolved images of 12,800 human proteins from just three landmark stains, thereby creating the "Proteome2Cell" dataset of 30.7 million virtual images to bridge the experimental scalability gap and enable comprehensive, single-cell spatial proteomics.

Sun, H., Kahnert, K., Hansen, J. N. + 7 more2026-04-02📄 cell biology

Genetic dissection of rapid proteolysis identifies TXNDC15 as a key factor of ERAD and lipid homeostasis

This study employs a genome-wide strategy to identify TXNDC15 as a novel, catalysis-independent essential factor in MARCHF6-mediated ERAD that regulates substrate exit from the ER and maintains lipid homeostasis.

Liu, Y., Yaochai, M. Y., Liu, S. + 2 more2026-04-02📄 cell biology

Molecular and functional characterization of telomeric repeat-containing RNAs in Chinese hamster ovary cells

This study establishes Chinese hamster ovary (CHO) cells as a robust model for investigating telomeric RNAs and reveals that ARIA transcripts, which originate from interstitial telomeric sequences, are essential regulators of telomeric DNA integrity by preventing the accumulation of single-stranded DNA at these sites.

Domingues-Silva, B., Azzalin, C. M.2026-04-02📄 cell biology

A non-invasive approach for understanding localized force generation in 3D tissues

This study introduces a non-invasive method using spontaneously engulfed elastic microbeads to reveal that 3D epithelial tissues generate localized, spatially segregated pulling and pushing forces through coordinated cytoskeletal dynamics, challenging the prevailing view of homogeneous force application.

Gouirand, N., Ibrahimi, M., Valotteau, C. + 7 more2026-04-02📄 cell biology

A Goldilocks principle of JAK/STAT signaling governs airway epithelial homeostasis and stress adaptation in Drosophila

This study establishes that airway epithelial homeostasis and stress adaptation in *Drosophila* are governed by a "Goldilocks principle" of JAK/STAT signaling, where balanced activity is essential for cell survival and integrity, while sustained overactivation drives pathological remodeling that is conserved across species and reversible via pharmacological inhibition.

Niu, X., Fink, C., Kallsen, K. + 10 more2026-04-01📄 cell biology

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