361 papers
Cell biology is the study of life at its most fundamental unit: the cell. This field explores how these microscopic building blocks function, communicate, and replicate to sustain living organisms, from the simplest bacteria to complex human tissues. By understanding the machinery inside a cell, scientists unlock secrets about growth, disease, and the very nature of existence itself.
At Gist.Science, we track every new preprint uploaded to bioRxiv within this dynamic category. Our team processes each submission to provide both accessible plain-language explanations and detailed technical summaries, ensuring you can grasp complex discoveries without getting lost in dense jargon. Below are the latest papers in cell biology, offering a fresh look at the inner workings of life as they are shared with the world.
This study elucidates the developmental regulation, intraflagellar transport-dependent trafficking mechanisms, and essential roles of the G-protein chaperone RIC-8 in the inversin compartment of C. elegans cilia and in human ciliogenesis.
The HuBMAP consortium addresses the challenge of operationalizing FAIR principles by developing and implementing a standardized, metadata-centered workflow that harmonizes diverse assay data into a compliant, open-access ecosystem, serving as a replicable model for other scientific communities.
This paper introduces LFCT, a comprehensive benchmark dataset featuring multi-day, low-frame-rate live-cell microscopy sequences with detailed ground-truth annotations, designed to evaluate and advance cell tracking algorithms capable of handling sparse temporal sampling and large inter-frame motion.
This study reveals that primary cilia in the growing mouse limb exhibit a preferential 45-degree orientation independent of their basal body position and ambulatory loading, suggesting a cell-intrinsic mechanism that ensures robust signal integration during endochondral ossification despite mechanical perturbations.
This study demonstrates that SUMO2-mediated sumoylation of p66Shc at lysine-81 promotes its phosphorylation and mitochondrial translocation, thereby driving hyperlipidemia-induced endothelial dysfunction and oxidative stress via the JAK-STAT signaling pathway.
This study establishes a robust DTNB-based high-throughput screening platform for comparative profiling of CPT1 isoforms, leading to the identification of vincamine as a selective CPT1b inhibitor and confirming chlorpromazine's activity against both CPT1a and CPT1b.
This paper introduces an open-source calculator that enables researchers to quantify and reduce the plastic waste and carbon emissions of cell culture protocols through evidence-based adjustments without compromising experimental efficiency.
This study reveals that the centrosomal protein PCNT contains intrinsic adaptor-like sequences within residues 1393–1525 that directly bind and activate the dynein motor for its co-translational transport to the centrosome, challenging the notion that dynein always requires separate adaptor proteins to engage its cargoes.
This study demonstrates that depleting the axonemal protein CCDC40 in *Trypanosoma brucei* disrupts axoneme structure and motility, leading to significantly shorter flagella and cells, yet surprisingly allows the parasites to grow and divide normally, thereby revealing distinct mechanisms governing trypanosome morphogenesis versus cell division.
This study demonstrates that a specific C-terminal structural element of the SKA3 subunit is essential for mediating the interaction between the SKA and NDC80 complexes at kinetochores, a critical step required for the successful transition from metaphase to anaphase during mitosis.